Sunday, July 13, 2014

Bits and Pieces: Writer's Block Edition (Also: Tecfidera, Crying Jags, the Price of MS Drugs, Underwater Wheelchairs, Asinine Research, and Some Funky Stuff)

(For those who receive Wheelchair Kamikaze via email, this post contains videos that can be viewed on the Wheelchair Kamikaze website – click here. They're really good videos, so I encourage you to check them out.)

I usually start these Bits and Pieces posts with thoughts and/or observations that have been rattling around inside my brain pan for the last several days or weeks, but somehow as I sit down to write this I’m experiencing nary a rattle. Truth be told I've been struggling with some writers block these last few weeks, pretty much for the first time since I started writing this blog over five years ago. I suppose it might only be expected after all of these posts, but geez, writer’s block sucks.

I suppose I could jabber on about how disappointed I am in the Boston Red Sox the season, or how much I’m looking forward to the new season of fantastic zombie TV show The Walking Dead (which doesn’t start until October, ugh), or how bummed I am that I missed seeing the new Godzilla movie in 3-D at the IMAX theater which is one block away from my apartment. Can you believe it? I LOVE Godzilla, and I missed the chance to see the beast from the deep in three dimensions on a screen 30 feet tall! How could I be so stupid?

Now, I don’t expect the new Godzilla movie to be anywhere near as good as the original 1954 Godzilla, and by original I mean the Japanese version, not the Americanized one that intercut scenes of Raymond Burr playing an American reporter in Tokyo during Godzilla’s onslaught into the sublime Japanese film, which is actually very introspective (well, as introspective as a movie about a prehistoric beast eating Tokyo can be), filled with nuanced references to Japan’s national angst about World War II, the horrors of atomic warfare, and the potential dangers of science run amok.

Speaking of Raymond Burr, did you know that he once owned his own private island in Fiji? I knew he was a successful actor who starred in some very popular TV series (Perry Mason, Ironsides) and had a very clandestine private life, but go know he had enough money to buy a private island. I sure would like a private island, although these days I guess a private island wouldn’t be much use to me, given my heat sensitivity issues and the fact that I don’t think sand and my wheelchair would get along very well. God, I hate having MS.

Okay, I guess that’s enough writing about nothing, so I might as well get to my latest collection of MS news items and other bits of info that have caught my attention and/or fancy over the past month or so. Hope you find them interesting, informative, entertaining, and worthwhile…

♦ The oral MS drug Tecfidera has been on the market here in the US for a little bit over a year, and a new study provides encouraging news about Tecfidera’s efficacy, while another furnishes some disconcerting data regarding the drug’s side effects. A paper released just this week demonstrates that Tecfidera is remarkably effective on newly diagnosed RRMS patients who have not previously been on other MS drugs (click here). Patients in the study took the drug either two or three times a day, and researchers found that Tecfidera reduced relapse rates by 56% and 60% in these groups, reduced the risk of relapse by 54% and 57%, reduced the number of new or enlarging lesions by 80% and 81%, and reduced Gadolinium enhancing lesions by 92%, when compared to patients taking a placebo. These numbers place Tecfidera amongst the most effective MS drugs available. No word yet on the effectiveness of the drug on patients who have had the disease for a longer duration, or who have already been on other treatments, but one would imagine that similar rates of effectiveness should be expected.

On the downside, another study looking at Tecfidera’s side effects found that gastrointestinal problems and flushing were reported by large numbers of patients taking the drug (click here). Although more serious side effects (such as opportunistic infections) were not reported, researchers found that gastrointestinal problems were severe enough to force roughly 10%-25 % of Tecfidera patients to stop taking the drug, depending on the MS clinic providing the data. Over 50% of Tecfidera patients required some kind of over-the-counter medications to help combat the initial side effects of taking the drug, although the majority of patients noted that these side effects subsided within three months of starting the drug. Seems that similar percentages of patients (10%-25%) experienced few if any side effects, and physicians are trying to find ways to ameliorate the incidence of side effects in their Tecfidera patients.

So, definitely a mixed bag on the Tecfidera front. Highly effective on the one hand, problematic side effects on the other (although no deadly side effects so far, thank heavens). As with all things MS, it seems it’s never easy…

♦ On one of the Internet MS forums I occasionally visit, a member was worried that they might be “cracking up” because they found themselves laughing or crying – sometimes uncontrollably – at the drop of a hat, and often at inappropriate moments. A little light bulb went off in my head (yes, I have light bulbs in my head, and they’re all of the old-fashioned incandescent variety) and I remembered a little known and talked about MS symptom called the pseudobulbar affect (click here). PBA, as it is called, is a symptom seen across a wide variety of disorders of the central nervous system which makes those afflicted with it highly prone to laughing and/or crying fits, usually completely beyond their control.

As might be expected, pseudobulbar affect can be very disturbing to those MS patients who suffer from it, especially if they don’t know that their out of whack emotions might be a symptom of their disease. A recent study found that about 10% of people with MS suffer from PBA (click here), so it’s more common than might be expected. Here is a little online quiz to check if you might have PBA (click here), thoughtfully provided by the drug company that (surprise!) makes a pill to combat it. Yes, there’s a pill for that! It’s called Nuedexta (click here). Now, this is just a guess, but I bet the pill is obscenely expensive. Hey, I just did a little googling (honestly, I did) and found that Nuedexta costs a mere $600 a month. Yikes! Yes, the price of MS meds forces one to laugh to keep from crying, and that has nothing to do with pseudobulbar affect.

♦ Speaking of the high price of MS drugs, five multiple sclerosis medications landed on a list of the 73 drugs whose prices have increased the most since 2007 (click here). Since that time, the price of Copaxone as increased 157%, Rebif 154%, Avonex 147%, Betaseron 133%, and Tysabri 102%. Given the fact that the first four of these drugs (the CRAB drugs) are the oldest MS “disease modifying therapies” and have been on the market for at least 15 years, one would expect their price to have decreased with time rather than increase. Apparently, though, logic plays no role when it comes to pricing MS drugs (and most other drugs, for that matter), as drug companies try to squeeze as much profit as possible out of their older drugs before patents expire and generic alternatives become available. Can’t say this isn’t a winning strategy for the drug companies, since Copaxone generated $4,000,000,000 (!) in sales last year and was the highest grossing MS drug on the market. Is it any wonder that more progress towards finding a cure hasn’t been made when huge gobs of money are being pocketed by keeping MS patients dependent on drugs that only “modify” the disease and most medical research is funded by the companies pocketing those gobs of money? An old saying about geese and golden eggs springs to mind.

♦ Okay, enough about drugs and drug companies, let’s move on to other vistas. How about some underwater ones? In this video (part of the terrific TED Talks series), artist Sue Austin takes my Wheelchair Kamikaze concept to new heights, or, more correctly, depths. After an extended illness left her disabled, Ms. Austin found the world shrinking, a feeling many of those with MS know all too well. As she eloquently expresses in the below video, before getting her wheelchair and exploring all of the potential it presented, she had internalized the limitations and dependencies that society seems subconsciously to want to impose on the disabled. When she got her powerchair, though, her world and all the possibilities contained within it suddenly burst wide open. The chair allowed her to explore unexpected directions in her visual artwork, and ultimately led her to take this new mode of creative expression under the sea. Yes, Sue Austin scuba dives in her wheelchair, and with style. Incredible, beautiful, and inspirational…

♦ The folks at the Made Strong company (click here) offer T-shirts and other items bearing their “Made Strong” credo, and they donate 10% of their profits to worthy causes (for MS, these monies go to the Race to Erase MS). I’m typically turned off by feel-good slogans and platitudes, especially when they have to do with the disease that has taken a wrecking ball to my life. The phrase “I Have MS but MS Doesn’t Have Me” makes me want to poke my eyeballs out with red-hot knitting needles. But there’s something about “Made Strong” that strikes a chord. There’s very little good I care to say about multiple sclerosis, but I do have to admit that struggling with MS and all the BS that goes along with it has made me a mentally stronger person even as the disease has whacked away at my physical self. I’m no longer the neurotic, anxiety riddled person that I used to be back in my healthy days. Dealing with this illness has led me to me confront some of my darkest fears and even my own mortality, forcing to the surface a mettle I honestly didn’t know I possessed. So, yeah, Made Strong, an MS slogan I can live with.

The Made Strong people have generously offered a 10% discount to Wheelchair Kamikaze readers. Just use the promo code WCK10 when ordering. (Full disclosure: Made Strong sent me a free T-shirt to introduce me to their products. Does this make me guilty of accepting a bribe? Maybe, but I promise that I wouldn’t have given them a word on this blog if I didn’t appreciate the sentiment expressed on their goods. I guess everybody has their price, but I’d hate to think that mine is as cheap as a T-shirt. Note to other product manufacturers: sending me free stuff will NOT guarantee you a place on these pages, but, on the offhand chance you’re interested, I do like cameras, vintage NYC World's Fair memorabilia, and exotic chocolates. Also, I really enjoy giving my wife jewelry, so diamonds 1.5 carats or larger set in white gold or platinum might get you a Wheelchair Kamikaze shout out. Just saying.)

♦ Okay, time for another installment of… asinine research (the crowd roars)! I’ve come across yet another study having to do with MS patients falling down (click here). What is it about multiple sclerosis and falling down that so fascinates researchers around the world? Seems to me that the two go hand-in-hand, MS and falling down, sex and pregnancy, beans and cornbread. This has to be the third or fourth “falling down” study I’ve featured here on WK, and I’ve passed up a few along the way.

Okay, so, this study compiled the results of a bunch of different studies from Australia, Sweden, United Kingdom, and the United States. Wait a minute, that’s three English-speaking countries out of four, and I’m pretty sure a lot of Swedish people speak pretty good English, so this immediately casts doubts on the validity of these results. Dammit, this study is biased against non-English-speaking multiple sclerosis patients who fall down! What, falling down in other languages doesn’t count? Don’t we all say “ow” when we fall down, no matter what our native tongue? If you prick us, do we not bleed? Must we constantly erect artificial barriers that keep us from seeing ourselves as one big family of man, instead giving way to tribalism and divisiveness, even when researching as eternally perplexing a subject as whether or not people with a potentially crippling disease fall down? Oh, the humanity!

Despite its jingoistic tendencies, this falling study does break some new ground (pun intended) as it defines MS patients who fall down as either “fallers” (those who fell only once during a during a three-month span) or “frequent fallers” (those who fell twice or more during the three-month span). My question is, do frequent fallers get some kind of gifts or rewards, like frequent flyers? Do they have exclusive access to luxurious waiting areas in their neurologists’ offices, replete with thickly padded floors and walls, where their every whim will be catered to as they tumble and crash to the ground? I mean, what good is it to qualify as a “frequent faller” if you can’t rack up those frequent faller points? Does accumulating enough frequent faller points allow for some kind of upgrade, like maybe to a neurologist who actually gives a shit? Of course, this study does nothing to address these issues. Stupid researchers.

What this study does reveal is shocking, simply shocking! “Most falls occur indoors (65%) between 6 AM and 6 PM (75%).” Gee, that couldn’t be because most MSers with mobility issues tend to spend a lot of time indoors, and – I’m guessing here, probably need to research this more fully – most falls don’t happen while sleeping, could it? “Primary progressive MS was associated with significantly increased odds of being a faller.” Who would’ve thought, given the fact that the most common first presenting symptom of PPMS is gait disturbances, that this form of the disease would lend itself to going kerplop? “Fall risk peaked at EDSS levels of 4.0 and 6.0…” Hmmm, EDSS 4.0 is defined as “fully ambulatory… despite relatively severe disability” and EDSS 6.0 calls for “intermittent or constant assistance (cane, crutch, or brace) required to walk about 325 feet”, so this study finds that patients whose disease has progressed far enough to produce “relatively severe disability” but not far enough to put them in a wheelchair face the greatest danger of taking a dive. Is Captain Obvious one of the authors of this paper? For their next research project, I suggest the authors study whether or not hitting yourself hard on the head with a hammer can cause a concussion. Hopefully by testing the hypothesis on themselves.

Seriously, though, the issue of PwMS suffering numerous falls is no joking matter, as I’ve known several folks who have really hurt themselves after taking a tumble. Here’s a page (click here) with some common sense tips on things that can be done to help prevent falls whether or not you have MS. And for all my MS friends out there, I think my best advice is to just use your head, and not as landing gear. I know we can all be very obstinate and loath to “give in” to the disease, but a broken hip or gashed forehead is too high a price to pay for pride. If you need help, ask for it. If doing something that used to be easy has become nearly impossible, just don’t do it, at least not without assistance. Easier said than done, I know, but MS can do enough damage without your giving it a helping hand.

♦ In my last “Bits and Pieces” post I concluded with a video by the musical artist Paolo Nutini, one of the musicians who are part of the neo-soul/retro-soul movement, making music that hearkens back to the funky, soulful sounds of the 1960s and 70s. Lots of readers commented on how much they enjoyed the video, and since I’m absolutely addicted to the stuff, I figured I’d make examples of the genre a regular part of these little compilations. So, feast your ears on Mr. Charles Bradley, who pours his guts out on every track he records. Part of the Daptone Records stable of artists, Charles Bradley may be considered a new artist, but he’s no young pup. He recorded his first album at the age of 62 in 2011, backed by the relentlessly funky Manahan Street Band. Mr. Bradley has lived a life filled with hardship and heartache, and his musical emergence is so unlikely that it’s almost impossible to believe. It’s captured in a terrific documentary called “Charles Bradley: Soul of America” (click here), which can be viewed on Amazon Prime streaming video. Throughout a lifetime spent living a hardscrabble existence, at times practically homeless, Bradley picked up gigs as a James Brown impersonator, an influence unmistakable in his recorded output.

So, without further fanfare, here is the righteous, mighteous, and out of sighteous Charles Bradley…


  1. Marc, informative as usual, but while you scream at T-shirts, I save my anger for measures of efficacy that don't really measure the effectiveness of a drug in MS such as the outcome measures you tick off for Tecfidera.

    Your readers might benefit from a review of these outcome measures starting with a presentation by George Ebers to a group convened by the European Medicines Agency that examines whether things like relapses and lesions counts are really clinically relevant outcome measures:

    1. Ed, are you saying that MS drugs give false hopes?
      If your not, I will!
      The 'benefits' of the drugs in the context of everyday day Life improvements and also the other angle of Quality of Life improvements is in reality the only relative measure.
      The benefit of most drugs, in any dis-ease situation, are generally measured as profitability successes and then that is re-written as a 'modification of disease' or in reality a modification from dis-ability to 'Profitability'!

    2. Edward and Nigel, thanks for your comments and always informative contributions to this blog. I'm put into the somewhat uncomfortable position of defending the products of the pharmaceutical companies; while I'm not a big fan of the medical research model in which these companies play so large a role, I'm also not so quick to discount the possible benefits of their products. This was not always the case – for quite a while I was highly skeptical that any of the MS drugs were of much use it all. I've learned through the years, though, that you've got a go where the science leads, and the science is starting to tell us that the DMT's, especially the newer generation, may in fact alter multiple sclerosis disease outcomes.

      First, a quick word on quality of life issues. I think it's beyond argument that for patients on whom the DMT's work quality of life can be tremendously improved. Patients seeing a significant decrease in relapses certainly also see a significant increase in quality of life, and this can't be discounted regardless of whether or not the drugs eventually stem progression to SPMS. Based on quality of life standards alone, even the older DMT's have value for the subset of patients on whom they work.

      As far as the relevance of relapses and lesions go, even in the YouTube video that Edward links to, Dr. Ebers notes that a lesser number of lesions early in the disease does seem to impact progression to SPMS. Therefore, there is some serious rationale to treating patients early and aggressively, before the disease "takes hold". The longitudinal study that Dr. Ebers refers to in his talk uses untreated patients for its accumulation of data. While this is of extreme value in understanding the natural history of untreated the disease, it only gives us a starting point when trying to ascertain whether or not the DMT's have significant impact on disease progression.

    3. Although the jury is certainly still out, the preponderance of newer evidence suggests that even the older DMT's (the CRAB drugs) do have a positive effect on disease outcome. Dr. Ebers himself co-authored a paper which demonstrated that the interferon drugs positively impact mortality in MS patients treated with them, stating "Recent results of the long-term follow-up study of interferon-β-1b demonstrated a significant reduction of mortality among treated patients" . I think we can all agree that a reduction in death rates is a pretty good outcome measure.

      Furthermore, the newer generation of MS drugs (Tysabri, Tecfidera, fingolimod etc.) are at least twice as effective on at least twice as many patients as the old generation CRAB drugs were, at least in regards to reducing relapse rates and lesion loads. While these drugs have not been in use long enough to fully ascertain their effect on long-term progression to SPMS, the data on Tysabri is starting to indicate that such a trend is a distinct possibility, with 64% of patients showing a reduction in disease progression. Not saying that Tysabri doesn't have its problems, and in some cases they can be deal breakers, but sometimes you have to give the devil his due. Other compounds such as Tecfidera and fingolimod, while known immunosuppressants, also hold out the possibility of neuroprotection, which could further the cause of delaying if not halting progression to SPMS.

      More draconian approaches to treating the disease are demonstrating startlingly good results when applied to patients soon after diagnosis, who are experiencing very active RRMS. HSCT (which Dr. Ebers has written about positively) and alemtuzumab, (Lemtrada) which both result in a "rebooted" immune system, are showing efficacy rates approaching 70% in keeping patients free of any evidence of disease activity for as long as seven years after treatment. This has been demonstrated in several recent studies (click here and here). I've spoken to a number of noted MS researchers about this, and was surprised to find that their thinking is that HSCT and possibly Lemtrada could very well become the standard of care for newly diagnosed patients with active RRMS, based on eye-popping results such as those found in the studies linked to in the previous sentence. Again, it's too soon to state whether or not these drugs delay or halt the onset of SPMS, but seven years plus of No Evidence of Disease Activity does at the very least seem promising, and I'm sure many patients would relish long-term remission of disease even if progression to SPMS was not delayed.

    4. Do I think that any of these therapies represents a "Holy Grail" of sorts? Absolutely not, and I'm disgusted that the hunt for the cause of MS has been placed on the back burner in many quarters, largely due to the profitability of the current crop of MS drugs. However, I can't let those emotions keep me from logically digesting the quantitative and qualitative evidence that is starting to come in regarding the efficacy of the next generation MS treatments. Given the latest data, it would be irresponsible at best to advise patients unequivocably to avoid these MS drugs or treatments.

      As for "false hopes", I would posit that some of the more popular "alternative therapies" have engendered quite a bit of false hope among a very vulnerable patient population, and that in some cases the hype accompanying these new therapies has far out raced any science backing them up. I've received far too many contacts from MS patients who have undergone alternative treatments in one form or another only to see their hopes dashed and pocketbooks smashed. Not saying that these new hypotheses and treatment modalities don't deserve serious and vigorous scientific investigation, but in some cases the cart has been put before the horse to the detriment of the MS patient population in general. Have some patients benefited from these treatments? Without question. Have more undergone treatment and seen little or no benefit whatsoever? Again, based on my numerous contacts with the community at large, I would say without question. Unfortunately, the testimony of those whose experience was negative, who generally remain quiet about being "failures", has been drowned out by the very vocal "true believers". Such is the nature of the Internet.

      In short, we are left with far too few answers and far too many questions in our quest to defeat MS. Still, there does seem to be a trend towards positive outcomes with the newer drugs, especially when they are applied to patients early in the disease course. Again, these drugs present their own set of problems, some quite serious, but to deny their impact at all is, at this point, a form of willful ignorance.

      The alternative therapies also show some promise, but in reality they are still immature and require much work before they can be talked about as anything but experimental.

      Again, thanks so much for your comments, and please keep them coming. Intelligent, open-minded give-and-take is the only way through the minefield of spin and misinformation that is the province of all sides of the MS treatment debate.

    5. Just realized I referred to HSCT as a drug, above. It's not, of course. For those who might be wondering, HSCT is a form of stem cell therapy in which the immune system is wiped out using very strong chemotherapy drugs, and then restored by way of a stem cell transplant.

  2. wow. lots to say with writer's block. good stuff. thanks dude.


    1. Yeah, even with writer's block I can't seem to keep it short. I'm definitely not a good candidate for twitter. Thanks for commenting…

  3. Lots to think about here, as usual, thank you! Esp. for the Charles Bradley link, great blues.

    1. Glad you liked the Charles Bradley, there's so much good "soul" out there that I'm like a kid in a candy store…

    2. Glad I waited until today to comment or I would have missed the wealth of information added later. I had no idea that any of the older drugs were more effective than placebo. Interesting stuff, that. Of course, as a person who has been PP, or at least SP, since being Dx'd, I keep hoping there'll be something for us other than a wing and a prayer for the future.

      Speaking of "something for us," thanks for the amazing Charles Bradley. Just what we midwesterners need--insider info from a real New Yorker on the latest finds in music.

      And another "something for us" is always the Asinine Research section. The particular topic you highlighted this time seems on a par with my 7th grade science project: cow eyeballs. Who is funding this stuff when they could get it done free by kids? But of course, kids in this century at this level of research would be no older than 4th graders!

    3. Hey Daphne, the meme that the older interferon drugs were no more effective than placebo was always a bit of a myth, since the drugs were trialed against placebo to begin with. Still, the jury is certainly still out on their overall effectiveness, but it does seem that for those patients on whom they work, they at the very least improve quality of life. The newer drugs hold much more promise, but are also much more problematic as far as side effect profiles go.

      It certainly would be nice if us progressive folks were thrown a bone every now and then, wouldn't it? It seems that now that the RRMS drug market has become saturated, attention is shifting to the progressive MS puzzle, but given the snails pace of research I'm sure that effective treatments are still years away. You never know, though, some type of paradigm shifting treatment (stem cells, maybe) may shake up the status quo and get things moving. At least that's what I keep telling myself.

      Glad you liked Charles Bradley, I'll include some more retro-soul in my next Bits and Pieces.

      Thanks for contributing to the blog

  4. I always suspected I am not alone in despising the cringe worthy phrase that MS doesn’t have me…. What BS – it does have me and affects everything I do, but especially my finances, which you point out so well about the drug cost increases. Obscene is the first word that comes to mind when talking about profits, but since our government won’t fund (much) medical research, the only way we might hope to find treatment and cure is through the Pharma $$s. Research finds we fall down? Yep, I read that study and laughed out loud. How about for a new topic we research the sex life of Perry Mason on that deserted island if he is there alone? The Sue Austin clip from her TED talk is wonderful – thanks for pointing out this one. There are so many take away messages from her.

    Thanks for introducing us to Charles Bradley – I am a huge fan of the funk sound of the 70’s. I lived in in Dayton, for our first 15+ years of married life some members of the Ohio Players lived one block away. We could see their gold records hanging on the wall. There are plans to build a Funk Hall of Fame here in Dayton, which is known as the birthplace of funk.

    I loved this wrap up and even though writer’s block sucks, it still made you produce some good stuff.

    1. Hi Laura, glad you liked this version of Bits and Pieces. "I have MS but…" has always driven me absolutely bonkers. Just seems to minimize the seriousness of multiple sclerosis as a disease, but sometimes it seems that's just what the mass media intends. As for the cost of MS drugs, the first words that spring to my mind are obscenities, but obscene is a great word to describe these outrageous prices.

      I'm loath to spread celebrity gossip, but looking into Raymond Burr's private life makes for some very interesting reading. Suffice it to say that his acting wasn't only confined to his dramatic roles, and he wasn't alone on that island in Fiji. Thankfully, times have changed enough so that many in the entertainment industry (and in society in general) no longer have to keep their private lives in the shadows for fear of losing their careers.

      How cool that you lived one block away from the Ohio Players. I didn't know that Dayton was the birthplace of funk. See that, you really do learn a new thing every day…

      Thanks for commenting…

  5. Great post. I love the idea of the Frequent Faller points. I could've racked up a ton of credits in the 1990s, back when I thought I was just a klutz. If only those points could get me 25% off my symptoms.

    As for the MS drugs, the two I tried, Avonex and Copaxone, both only made me worse. Although diagnosed as RRMS, I'm almost positive I never was. Of course, where's the percentage in diagnosing PPMS? No drugs for that. Might as well claim it's RRMS and grab the cash before they figure out they're just being hosed.

    Thanks for the link to Charles Bradley. Great sound.

  6. Thanks for your great write-up about the dumb, waste-of-money research. Here's my own important idea for a study (it definitely demands a million-dollar research grant). You've mentioned your ties to The Twilight Zone. Well, true story, but just prior to my own MS diagnosis, I watched quite a few episodes of TZ! In a nutshell -- or perhaps, in a chunk of cheese -- my proposed study involves mice and tiny televisions. Some rodents, unfortunately for them, will not be allowed to watch TV. Others will exclusively view TZ. Will MS-like symptoms be higher in the TZ mice? If necessary, to fancy things up and receive more funding, other groups can be added. Does the picture change (no pun intended) if some of the mice watch The Monkees? Original Jonny Quest cartoons?

    Thanks again for your terrific blog!

  7. Love your idea for some MS research. It would be a true Twilight Zone twist if the researchers all got MS while the mice watched TV. Thanks for your comments…